Objectives: The clinical efficacy of stromal vascular fraction (SVF) and platelet-rich fibrin (PRF) for the treatment of thermal wounds after enzymatic debridement is evaluated.

Introduction: Enzymatic debridement for severe burn injuries is an attractive alternative to conventional invasive excision by knife. Bromelain-based enzymes extracted from pineapples permit a selective removal of burn eschar that preserves the dermis and thus grants improved long-term outcomes. Once the burn eschar is removed, it presents a promising scaffold for autologous cells and growth factors to stimulate the body-own regeneration with the ultimate goal to circumvent skin grafting.

Materials / method: In this study, patients with deep partial thickness burns (DPTBs) that were treated at the Burn Center of the Zurich University Hospital underwent enzymatic debridement of selected areas followed by autologous SVF-PRF treatment. Outcome including time to epithelization, complications, and the need for skin grafting were evaluated.

Results: A total of 13 patients (7 male, 6 female) underwent the afore-mentioned treatment. The average injured total burn surface area (TBSA) was 6.83%. The time to heal varied heavily and ranged from 10-42 days. Five patients needed subsequent skin grafting due to insufficient healing. Beyond incomplete wound healing, no other therapy-related complications were observed.

Conclusion: In theory, the combination of enzymatic debridement and SVF-PRF application is an appealing, regenerative approach that in practice, however, requires further optimization as it cannot level autologous skin grafting as the gold standard.

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Objectives: While a considerable number of cases with rosacea are resistant to conventional medications, therapeutic regimens are not currently established. Pu

fractional microneedling radiofrequency (FMR) have previously demonstrated satisfactory results for anti-angiogenesis, anti-inflammation, and dermal remodeling and in addition to that we have added platelet rich plasma to the treatment to increase the efficacy of treatment

Introduction: To evaluate the efficacy and safety of novel combination regimen with low-dose oral isotretinoin, PRP, and FMR in the treatment of recalcitrant Rosacea in patients with skin of color.

Materials / method: A retrospective studies were undertaken for recalcitrant rosacea patients with skin of color to evaluate the clinical course of novel combination regimen.
Case study of 5 patients has been discussed who has been treated successfully with the above regimen

Results: And all patients achieved excellent improvement in the erythema of rosacea with long term maintainance of achieved results
No serious side effect was observed during whole study periods

Conclusion: This novel combination regimen demonstrated satisfactory efficacy with reasonable safety profiles for the treatment of recalcitrant rosacea in patients with skin of color

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