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Objectives: Objective: To assess the combined efficacy of Fractional Picosecond Laser (FPL) and plant-derived stem cell exosome therapy for male Androgenetic Alopecia (AGA) treatment.

Introduction: Exosomes play a pivotal role in hair morphogenesis and regeneration, offering novel avenues for alopecia treatments. Particularly, exosomes derived from stem cells exhibit properties that can stimulate hair follicle development and cycling.

Materials / method: This was a pilot study in 5 male participants treated with a 1064-nm FPL for mild-to-moderate AGA and then were applied with topical exosomes. The patients underwent 5 treatments at 4-week intervals, followed by a 4-week post-procedure assessment. Expert panel assessment score and patient satisfaction was assessed using a 7-point scale. Dermoscopic analysis was conducted to evaluate hair shafts. Adverse effects were also monitored.

Results: Significant clinical improvement in hair density and thickness was observed from 1 to 6 months post-treatment, with notable increases in expert panel assessment scores and patient satisfaction. Minimal adverse effects were reported, resolving swiftly. Dermoscopic analysis confirmed the safety of the treatment, showing minimal petechiae without hair shaft damage.

Conclusion: The study underscores the potential of combining 1064-nm FPL with topical plant-derived stem cell exosomes in promoting hair regrowth in male AGA. These findings highlight the role of exosomes in hair follicle development and regeneration, encouraging further research to optimize this promising treatment approach.

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Objectives: Better treatment , less side effects

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Objectives: This study aims to evaluate the combined effects of botulinum toxin and exosome therapy on hair loss over one year, utilizing data from twelve cases across four countries following a unified protocol. Additionally, the study explores the results among different races and age groups.

Introduction: Hair loss is a global concern, prompting the exploration of innovative treatments. Botulinum toxin and exosome therapy offer distinct mechanisms of action and show promise in addressing this issue. This study investigates the synergistic effects of combining these therapies, drawing on data from twelve cases spanning four countries. Results among different racial and age groups are also examined

Materials / method: Twelve cases meeting predefined criteria from four countries were enrolled in this study. Participants received combined botulinum toxin and exosome therapy according to a unified protocol. Hair shedding, density, and thickness were evaluated as primary outcomes over a six-month period using standardized criteria

Results: Significant improvements in hair shedding, density, and thickness were observed among participants following the combined therapy. Statistical analysis supported the efficacy of this approach, indicating its potential as a promising treatment for hair loss. Younger patients demonstrated better outcomes, and Caucasians experienced quicker effects compared to Asians. Additionally, positive results were noted among black individuals with curly hair

Conclusion: The findings suggest that combining botulinum toxin and exosome therapy holds promise in addressing hair loss. Integration of this approach into existing treatment regimens may improve outcomes. However, further research, including larger trials and mechanistic studies, is necessary to fully understand its potential and optimize its clinical application.

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Objectives: There has always been a quest to develop newer therapies for hair loss including AGA. Many therapies including topical finasteride, LLLL, PRP, Mesotherapy, Stem cell therapy, peptides have been tried and all have shown promise in various studies. Mesotherapy and stem cell micrografting has particularly evolved in the recent past and has shown promise

WE have been working on transfer of autologous stem cells, derived from the the patient's skin, to the balding areas for induction of hair growth

Introduction: Over thousands of years, Scientists have worked to establish various treatment modalities in Healthcare services. In 18th century, They revealed that all life depends on chemical reactions that occur within cells, which could, in fact, be reproduced in the laboratory. The discovery of cell division and heritability in the form DNA was geared to bring ‘a whole other ball game of Stem cell and Regenerative treatments.
Regenerative medicine has grown to extent of Cell therapy, Surgical implants & skin grafts.

Materials / method: In this study 2.5 mm punch grafts taken from the reteroauricular areas were subjected to intense crushing in a special chamber of the Rigenera machine. This machine rotates at a speed of 80 revolutions per min and the special perforated base and the blades break down the the skin into a fine paste that contains the stem cells derived from the hair follicle and the adipose tissue in the punches. this is suspended in normal saline and the final solution is injected into the balding area using the deep mesotherapy technique.

Results: Most of the patients of grade II to III stage AGA did quite well and had a good stimulation of hair growth within 2 to 3 months of the procedure. The effects were sustained for upto one and a half year in most of the patients.

Needless to mention that the medical treatment was continued in most of these patients during and after the procedure

Conclusion: In this era of dearth of certified and effective therapies for androgenetic alopecia where we have just oral finasteride and topical minoxidil as approved drugs by the USFDA, there is a huge requirement for development of newer therapies

Autologous stem cell therapy has come as a welcome boon for these patients and for the hair physicians for better management of this difficult and lifelong hair disorder.

This can be a great adjunct to the medical treatment of AGA

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